Mucous content was increased and accompanied by proportionate increase in proteins and hexo. Gastric total acid output and pepsin activity were estimated in the pylorus ligated rats. The plant contains kaempferol, a cyanogenetic glucoside. After 14days treatment, animals were fasted for 24 h.
Key words anti ulcer, acacia farnesiana, folk medicine, aroma. Gastric ulcer disease has become a disease predominantly affecting the older population, with the peak incidence occurring between. Aroma is offering an ineffable support to the folk medicine, which is a traditional medicine for the treatment of ulcers in india. Antiulcer activity was evaluated by measuring ulcer index and percentage of ulcer healing. Elida did the survey data in the database and will format the manuscript. Invivo models used for preclinical evaluation of antiulcer activity. The plant kingdom holds many species containing substances of medicinal properties. International journal of farmacia journal home page.
In vitro antioxidant capacity and in vivo antiulcer and. Approximate coordinates for all nonhydrogen atoms of 33 and 34 were obtained from initial maps. Biological methods of drug evaluation your article library. Analysis of curcumin content of turmeric samples from various states of india geethanjali a, lalitha p and jannathul firdhouse m. The effects of the tuber extract were evaluated on cold stress and aspirin induced ulcer models in rats. Analysis of curcumin content of turmeric samples from various. Review article clinical and therapeutic benefits of centella asiatica kulsoom zahara, yamin bibi and shaista tabassum department of botany, pmas arid agriculture university rawalpindi, pakistan corresponding authors email. Results showed the presence of flavonoids and proteins. Phytochemical screening and antimicrobial activity of the plant extracts of mimosa pudica l. Mda and mpo activity were also significantly p antiulcer and gastroprotective activity against ethanol induced gastric ulcers.
Antiulcer activity of dichloromethane fraction dcmf of stem barks from boswelli dalzielii hutch was studied in rats by administration of ethanolinduced method and by pyloric ligation method. Evaluation of antiulcer activity of methanolic extract of terminalia chebula fruits in experimental rats raju. The hydroalcoholic extract of glycyrrhiza glabra l. Analgesic, antipyretic and antiulcer activities of ailanthus. Antiulcer activity of protocatechuic acid ethyl ester was studied in rats in which gastric ulcers were induced by oral administration of ethanol or aspirin or by pyloric ligation. Analgesic and antipyretic activities were evaluated by using hot plate test at doses of 50 mg kg and 100 mgkg of the extracts. Antiulceration activity study conducted in 1982 by andersen et al, has concluded that squid ink possesses marked antiulcer activity by. Drugs of plant origin are gaining popularity and are being investigated for a number of disorders, including peptic ulcer. The anti gastric ulcer activity of pisonia aculeata leaf extracts in pylorus ligation model is evident from its significant reduction in gastric volume, free acidity, total acidity, ulcer score and increase in p h when compared to that of standard drug.
All the rats in all four groups were pretreated with respective drugs for five days in two daily divided. Pdf antiulcer activity of water soaked glycine max l. Analgesic, antipyretic and antiulcer activities of. Persisting peptic ulcer leads to complications like gastrointestinal bleeding, gastric perforation and pyloric obstruction. The antiulcer activity of methanolic extract of terminalia chebula combretaceae fruits metc was investigated in pylorus ligation and ethanol induced ulcer.
Wide spread use of herbs throughout the globe has raised serious concerns over its quality, safety, and efficacy. Some recent reports have indicated that many flavonoids possess antiulcerogenic activity. Oral treatment with the ether fraction of the flavonoid extract demonstrated a good level of gastric protection. The present investigation revealed that ocimum sanctum exhibited significant antiulcer activity by enhancing antioxidant potential of gastric mucosa thereby. It is remarkably nontoxic and exhibits limited bioavailability. Original article aripiprazole an atypical antipsychotic. Alcoholic extracts at 400 mgkg and 600 mgkg showed significant 0. Find powerpoint presentations and slides using the power of, find free presentations research about antiulcer activity ppt. May, 2017 1644 ocimum sanctum lamiaceae is commonly known as holy basil. Pdf assessment of antiulcer activity of corbichonia. Cimetidine was used as a standard drug for the cold stress induced ulcer model. Protective effect of standardized extract of cleome viscosa against animals.
Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 510% of people during their life. The antiulcer activity was performed using the coldrestraint stress induced ulcer. Antiulcer and antiinflammatory activity of aerial parts. Article full text enhanced pdf format, 26376 bytes. The antiulcer activity was assessed by determining and comparing the ulcer index in the test drug group with that of the vehicle control group. The experiment was performed using the method of shay et al, with a few modifications. Ulcers occur within the stomach and or duodenum and are often chronic in nature. Antiulcer activity of dodonaea viscosa leaf extract in aspirin induced albino rats introduction an ulcer is defined as disruption of the mucosal integrity of the stomach and or duodenum leading to a local defects or excavation due to active inflammation. The antiulcer activity of fresh juice extract of the roots of carrot was assessed by the parameters i. Hydrogen atoms were located in a difference fourier synthesis evaluated following several rounds of fullmatrix leastsquares refinement of nonhydrogen atom positional and. The antiulcer and in vitro antiinflammatory activities of the aerial parts of enicostemma littorale against aspirin, ethanol, and pyloric ligationinduced ulcers in rats and bovine serum albumin denaturation were studied.
Evaluation of antiulcer activity of methanolic extract of terminalia. Antiulcer activity and potential mechanism of action of the leaves of. Minocycline in doses of 10, 30 and 100 mgkg body weight was given intraperitoneally i. It is used in brazil for culinary purposes and in folk medicine to treat liver and gastric dysfunctions, as well as hangovers. Antiulcer activity of ficus religiosa leaf ethanolic extract. Phytochemical screening and antiulcer activity of jasminum mesnyi and triticum aestivum leaves in albino wistar rats mehnoor farheen, sobia farheen. Evaluation of antiulcer activity of aqueous extract of.
Transcriptase mmlvrt and have exhibited antiretroviral activity. One such drug, the antidepressant mirtazapine, has been reported to have an antiulcer effect that involves an increase in antioxidant, and a decrease in oxidant, parameters. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. Antiulcer activity of aqueous and ethanolic extracts of ocimum. Also ear lier studi es in west africa have reported the wound healing and antiulcer activity of its nhexane and methanolic extracts okoli et al. Antiulcer cleome pdf in vivo antiulcer and in vitro antioxidant activity of barleria gibsoni was and characterization of polyphenol oxidase from leaves of cleome gynandra pdf fingers menu. Antiinflammatory, antioxidants, antiulcer, enicostemma littorale doi. Although many drugs are available for the treatment of gastric ulcers, often these drugs are ineffective. Each rat was administered the desired concentration of the drug in a volume of 0. Gandhiraja n, sriram s, meena v, srilakshmi k, sasikumar c, rajeshwari r.
A, normal saline and ranitidine on histamine induced ulcer in rats. Antiulcer activity of essential oil constituents mdpi. Kundnani college of pharmacy, jote joy building, rambhau salgaonkar marg, cuffe parade, colaba, mumbai 400005, india. Antiulcer activity of the leaf ethanolic extract of mimosa pudica in rats. Many antidepressant drugs have been shown to have antiulcer activity in various models of experimental ulcer. In southea stern nigeria, lea ves of t his pl ant i s clai med to be effect ive in the treatment of stomach ache and. Evaluation of antiulcer activity of protocatechuic acid. Evaluation of antiulcer activity of methanolic extract of. Evaluation of the antiulcer properties of castor plants. Evaluation of antiulcer activity of protocatechuic acid ethyl. Original article gastroprotective effect of minocycline in.
Preliminary phytochemical screening and acute toxicity studies of f. Methanolic extract by aspirin plus pyloric ligation model. Hegg was evaluated for antiulcerogenic activity and acute toxicity profile in mice. It is one of the sacred herbs for hindus in the indian subcontinent. Curcumin is a free radical scavenger with rich antioxidant activity, binds metals, particularly iron and copper, and can function as an iron chelator. Protocatechuic acid ethyl ester was administered in the dose of 30 mgkg and 60. The extracts have similar analgesic activity and the ether extract showed good analgesic activity at 30 min. The antiulcer activity of kantha chendooram at both the dose levels of 20 mgkg and 40 mgkg produced a significant decrease in the ulcer index p antiulcer properties 4. Various doses of hegg 50200 mgkg were administered orally to animals of different groups. Antiulcer, borassus flabellifer linn, aspirin pylorus ligation, ethanol induced ulcer, ranitidine. Assessment of antiulcer activity of corbichonia decumbens forsk. Investigation into the antiulcer activity of the aqueous. Antiulcer activity of the methanolic extract of the leaves of k.
Analysis of curcumin content of turmeric samples from. Acalypha indica can be useful in treating pneumoniae, asthma, rheumatism and several other ailments. New steroidal saponins and antiulcer activity from solanum. Ulcer was induced by administration of aqueous suspension of indomethacin 30 mgkg, and 6 h later, the animals were sacrificed 10. The antiulcer activity of aqueous extract of the leaves of murraya koenigii was evaluated by using models of acute gastric lesions induced by ethanol induced. Date ddmm a potential of some medicinal plants as an. Review article clinical and therapeutic benefits of centella. The histopathological study of stomach also supported the above results. Over the past decades, herbal medicine has become a thing of global significance with medicinal and economic implications.
The present investigation revealed that ocimum sanctum exhibited significant antiulcer activity by enhancing antioxidant potential of gastric mucosa thereby reducing mucosal damage. View and download powerpoint presentations on antiulcer activity ppt. Therefore the antiulcer activity of hydroalcoholic extract of g. Evaluation of antiulcer activity of boswellia serrata bark. Solanaceae is a plant species widespread throughout tropical america, especially in the brazilian savanna region. Egyptian origin were evaluated for their analgesic, antipyretic and antiulcer activities.
The extract 200 mgkg and 400 mgkg po was administered to the overnight fasted rats, one hour prior to aspirin. The phytochemical analysis carried out revealed the presence of saponins, tannins, flavonoids, carbohydrates, amino acids and. The antiulcer activity of the tubers of ipomoea batatas sweet potato was studied in cold stress and aspirininduced gastric ulcers in wistar rats. Gastric fluid total acidity and free acidity were estimated in pylorus ligated rats. Gastric ulcers induced with ethanol and ethanolhcl are the most commonly utilized experimental models for the evaluation of antiulcer activity in mice. Phytochemical screening and antiulcer activity of jasminum mesnyi and triticum aestivum leaves in albino wistar rats mehnoor farheen, sobia farheen shadan womens college of pharmacy, khairatabad, telangana state, hyderabad500004 email. New steroidalsaponins and antiulcer activity from solanumpaniculatuml.
Consequently we have evaluated the anti ulcer activity of meaf. Antiulcer activity of pisonia aculeata on pylorus ligation. During this time they are housed single in cages with raised bottoms of wide wire mesh in order to avoid cannibalism and coprophagy. The three flavnoids present in the crude extract and enriched in flavnoid fraction are rutin, aspigenin7oglucoside and luteolin7oglucoside. One such drug, the antidepressant mirtazapine, has been reported to have an antiulcer effect that involves an increase in antioxidant, and a decrease in. Sharath s s1, preethy j1, surendra kumar g1, revannaswamy a1, muralidhar p1, sujith tumkur rajashekar3, prabhavathi2, rohini kr1. These observations suggest that sucralfates antiulcer activity is the result of formation of an ulceradherent complex that covers the ulcer site and protects it against further attack by acid, pepsin, and bile salts. Hence, it establishes the fact that the methanol extract of antiulcer activity of acacia farnesiana l.
K1 1department of pharmacology, srm college of pharmacy, srm university, kattankulathur 603 203, kancheepuram dt,tamilnadu, india. Article full text enhanced pdf format, 25493 bytes. Evaluation of antiulcer activity of moringa oleifera seed extract. Seeds extract of moringa oleifera was administered in the dose of 150 and 200 mgkg orally. The antigastric ulcer activity of 90% ethanolic extract at 200mgkg is. The effects of the formulation at two different does 375 mgkg and 750 mgkg on gastric juice volume, ph, total acidity, ulcer score, ulcer index and % inhibition. Our study investigated the antiulcer activity of s. Antiulcer activity of ipomoea batatas tubers sweet potato.
The petroleum ether 250mgkg and aqueous extracts 250mgkg of bark of boswellia serrata plant showed significant antiulcer activity as evifindings also confirm the antiulcer activity of boswellia serrata bark extracts in albino rats. The daucus carota extract possesses gastro protective property and the results supported traditional use of the roots of. Here, the present study was carried out to investigate antiulcer activity of ethanolic extract of madhuca. Review article clinical and therapeutic benefits of. Female wister rats weighing 150170 g are starved for 48 h having access to drinking water ad libitum. Consequently, the objective of the present study was to validate the antiulcer effect attributed to g. Evaluation of antiulcer activity of ethanolic extract of. Adult wistar albino rats of either sex weighing 180200 g were used for the study. Evaluation of antiulcer activity of moringa oleifera seed.
The ulcer index of protocatechuic acid ethyl ester treated rat was comparable to those of ulcerated control rats. Antiulcer activity of seeds of moringa oleifera was studied in rats in which gastric ulcers were induced by oral administration of ethanol and pylorus ligation. In vivo antihelicobacter pylori activity of methanolic. The antiulcer activity was carried out employing pyloric ligation method shay rat model9 procedure. Protocatechuic acid ethyl ester was administered in the dose of 30 mgkg and 60 mgkg i. The creation of ethanolinduced gastric lesions is of multifactorial origin with decrease in gastric mucus amount as one of the involved factors. In the present study, protocatechuic acid ethyl ester has potent ulcer protective activity at a dose 30 mgkg and 60 mgkg, but at the dose 60 mgkg was more potent.
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